KD of integrin 1 attenuated the localization of both Abi1 and Pfn-1 at the leading edge (Fig.?6C,D). Open in a separate window Figure 6 Integrin 1 controls the positioning of Abi1 and Pfn-1 at tip of protrusion. lamellipodia and its protrusion coordinated with F-actin at the leading cell edge of … Continue reading KD of integrin 1 attenuated the localization of both Abi1 and Pfn-1 at the leading edge (Fig